2-Methyl-1,3-propanediol
[CAS# 2163-42-0]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Alcohol
• Name: 2-Methyl-1,3-propanediol
• Molecular Formula: C₄H₁₀O₂
• Molecular Weight: 90.12
• CAS Registry Number: 2163-42-0
• EC Number: 412-350-5
• SMILES: CC(CO)CO

Properties

• Density: 1.015
• Melting point: -91 ºC
• Boiling point: 123-125 ºC (20 mmHg)
• Refractive index: 1.445
• Flash point: 100 ºC

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H315-H319-H335
• Precautionary Statements: P261-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2A	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovory and Applicatios

2-Methyl-1,3-propanediol, also known as MPD or neopentyl glycol, is an organic compound with the chemical formula C5H12O2. This colorless, odorless liquid is a diol, characterized by the presence of two hydroxyl (–OH) groups. The discovery of 2-methyl-1,3-propanediol dates back to the early 20th century when it was first synthesized through the hydrogenation of 2-methyl-1,3-butadiene, also known as isoprene. Over the decades, researchers have focused on understanding its properties and potential applications, leading to its current significance in various industrial sectors.

The synthesis of 2-methyl-1,3-propanediol typically involves several chemical reactions, including the oxidation of hydrocarbons and the subsequent reduction processes. One of the most common methods for producing this compound is through the catalytic hydrogenation of isoprene, which allows for a more efficient and environmentally friendly approach. The resulting product possesses unique physical and chemical properties that make it suitable for various applications.

One of the primary uses of 2-methyl-1,3-propanediol is as a building block in the production of polyester resins and plastics. It acts as a diol component in the synthesis of polyesters, which are widely used in coatings, adhesives, and textiles. The incorporation of MPD into these materials enhances their thermal stability and mechanical properties, making them more durable and versatile for industrial applications.

Additionally, 2-methyl-1,3-propanediol is utilized as a solvent and a reagent in organic synthesis. Its excellent solubility in water and organic solvents enables its use in various chemical processes, including the formulation of inks, dyes, and other chemical products. The compound's low toxicity and compatibility with other substances make it an attractive option for manufacturers seeking safer alternatives for their products.

The pharmaceutical industry also recognizes the potential of 2-methyl-1,3-propanediol as an excipient and stabilizer in drug formulations. Its ability to enhance the solubility and stability of active pharmaceutical ingredients (APIs) has led to its incorporation in various medicinal products. Research continues to explore its effectiveness in drug delivery systems and its role in improving the bioavailability of certain compounds.

In the field of cosmetics and personal care, 2-methyl-1,3-propanediol is employed as a humectant and emollient. Its moisturizing properties help maintain skin hydration and improve the texture of cosmetic formulations. Furthermore, it is often included in formulations for hair care products, where it aids in conditioning and enhancing shine.

Despite its numerous applications, safety considerations regarding 2-methyl-1,3-propanediol are paramount. Regulatory agencies monitor its usage to ensure it meets safety standards for consumer products. Manufacturers are required to adhere to guidelines to mitigate potential health risks associated with its application.

In summary, 2-methyl-1,3-propanediol is a versatile chemical compound with diverse applications in the fields of plastics, pharmaceuticals, cosmetics, and organic synthesis. Its discovery and subsequent development have made significant contributions to various industries, emphasizing the importance of ongoing research and innovation in the utilization of this valuable compound.