2-Methyl-2-propanaminium (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate
[CAS# 917805-74-4]

Identification

• Classification: Flavors and spices >> Synthetic spice >> Carboxylic acid and ester perfume >> Other carboxylic acid esters
• Name: 2-Methyl-2-propanaminium (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate
• Synonyms: tert-butylazanium (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
• Molecular Formula: C₂₆H₃₉FN₄O₆S
• Molecular Weight: 554.67
• CAS Registry Number: 917805-74-4
• EC Number: 682-385-0
• SMILES: CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.CC(C)(C)[NH3+]

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302
• Precautionary Statements: P264-P270-P301+P317-P330-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302

Discovory and Applicatios

2-Methyl-2-propanaminium (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate, commonly known as albuterol sulfate, belongs to the class of medications called bronchodilators. Albuterol sulfate was discovered in the late 1960s as part of efforts to develop effective treatments for bronchospasm associated with asthma and other respiratory conditions. The compound's ability to relax the smooth muscles of the airways and improve breathing made it a breakthrough in the management of asthma and chronic obstructive pulmonary disease (COPD).

Albuterol sulfate is widely used as a rescue inhaler to relieve acute symptoms of asthma, including wheezing, shortness of breath, and chest tightness. It works by relaxing the muscles around the airways, allowing them to open up and improve airflow. Albuterol sulfate provides rapid relief during asthma attacks and is an essential medication for managing asthma symptoms.

Albuterol sulfate is also prescribed for patients with COPD, including chronic bronchitis and emphysema. It helps to alleviate bronchospasm and improve lung function, making breathing easier for individuals with COPD. Albuterol sulfate may be used as needed for acute exacerbations or as part of a maintenance regimen to manage symptoms and improve quality of life.

Individuals who experience exercise-induced bronchoconstriction, also known as exercise-induced asthma, may benefit from using albuterol sulfate before physical activity to prevent symptoms such as coughing and wheezing. Albuterol sulfate helps to open up the airways and reduce the risk of bronchospasm triggered by exercise.

Albuterol sulfate is safe and effective for use in children with asthma. It is often prescribed to children as a rescue medication to relieve asthma symptoms quickly. Pediatric formulations of albuterol sulfate are available in metered-dose inhalers (MDIs) and nebulizer solutions, making it easy to administer to young patients.

In addition to its use as a rescue medication, albuterol sulfate may be prescribed as a preventive treatment for asthma symptoms in some patients. When used regularly, it can help to control asthma symptoms and reduce the frequency and severity of asthma attacks, improving overall lung function and quality of life.

Albuterol sulfate is commonly administered in hospital settings for the treatment of severe asthma exacerbations and acute respiratory distress. It may be delivered via nebulization or through intravenous infusion in critical care units to rapidly relieve bronchospasm and improve oxygenation in patients with respiratory emergencies.