4-(Trifluoromethyl)-5-pyrimidinecarboxylic acid
[CAS# 220880-12-6]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Methyl pyrimidine
• Name: 4-(Trifluoromethyl)-5-pyrimidinecarboxylic acid
• Molecular Formula: C₆H₃F₃N₂O₂
• Molecular Weight: 192.10
• CAS Registry Number: 220880-12-6
• EC Number: 880-995-3

Properties

• Solubility: Sparingly soluble (23 g/L) (25 ºC), Calc.^*
• Density: 1.575±0.06 g/cm³ (20 ºC 760 Torr), Calc.^*
• Melting point: 146-148 ºC (chloroform )^**
• Boiling point: 291.0±40.0 ºC (760 Torr), Calc.^*
• Flash point: 129.8±27.3 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2019 ACD/Labs)

^** Schlosser, Manfred; European Journal of Organic Chemistry 2006, (6), P1593-1598.

Safety Data

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2A	H319
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H302