Malonic acid disodium salt monohydrate
[CAS# 26522-85-0]

Identification

• Classification: Organic raw materials >> Organometallic salt
• Name: Malonic acid disodium salt monohydrate
• Synonyms: disodium propanedioate hydrate
• Molecular Formula: C₃H₂Na₂O₄^.H₂O
• Molecular Weight: 166.04
• CAS Registry Number: 26522-85-0
• SMILES: C(C(=O)[O-])C(=O)[O-].O.[Na+].[Na+]

Discovory and Applicatios

Malonic acid disodium salt monohydrate, with the molecular formula C3H3Na2O4·H2O, is a sodium salt of malonic acid. This compound plays a significant role in organic chemistry and biochemistry due to its unique properties and versatility. Malonic acid itself was first identified in the early 19th century from the fermentation of apple juice, leading to its name derived from the Greek word for apple, "malon." The disodium salt form was later developed to enhance its solubility and utility in various applications.

The synthesis of malonic acid disodium salt monohydrate typically involves the neutralization of malonic acid with sodium hydroxide or sodium carbonate. This reaction results in the formation of the disodium salt, which can be crystallized in the presence of water to yield the monohydrate form. The solubility of this compound in water makes it particularly useful in biological and chemical applications.

One of the primary applications of malonic acid disodium salt monohydrate is in the field of biochemistry. It serves as a key intermediate in the synthesis of various pharmaceuticals and biochemicals. Its ability to participate in nucleophilic substitution reactions makes it a valuable building block for the construction of complex organic molecules. The compound is often used in the synthesis of barbiturates, which are important classes of drugs used for their sedative and anesthetic properties.

In addition to its pharmaceutical applications, malonic acid disodium salt monohydrate is also used as a buffering agent in biological research. Its capacity to maintain a stable pH in solutions is crucial for various biochemical experiments and assays. This property is particularly important in enzyme assays and other applications where pH fluctuations could affect the outcome of reactions.

Furthermore, this compound finds utility in the synthesis of polymers and agricultural chemicals. It can act as a precursor in the production of biodegradable polymers, contributing to environmentally friendly materials. Additionally, its derivatives are employed in the formulation of herbicides and pesticides, enhancing the efficacy of agricultural products.

Malonic acid disodium salt monohydrate also has applications in the food industry as an acidulant, flavoring agent, and preservative. Its ability to enhance the flavor profile of food products while contributing to food safety makes it a valuable ingredient in various formulations.

The discovery and application of malonic acid disodium salt monohydrate exemplify its significance in organic synthesis, biochemistry, and industrial applications. Its versatility and reactivity continue to make it an important compound in the development of pharmaceuticals, polymers, and food products.

References

2016. Perfect hemihedral twinning in crystals of the γ-subunit of translation initiation factor 2 from Sulfolobus solfataricus: Cause and effect. Biochemistry. Biokhimiia.
DOI: 10.1134/s0006297916100187

2012. New tungstenocenes containing 3-hydroxy-4-pyrone ligands: antiproliferative activity on HT-29 and MCF-7 cell lines and binding to human serum albumin studied by fluorescence spectroscopy and molecular modeling methods. Journal of Biological Inorganic Chemistry.
DOI: 10.1007/s00775-012-0964-2

1997. Oxygen, Sodium, Magnesium. Nuclear Quadrupole Resonance Spectroscopy Data.
DOI: 10.1007/10565418_23