Chlorambucil
[CAS# 305-03-3]

Identification

• Classification: API >> Antineoplastic agents >> Alkylating agent
• Name: Chlorambucil
• Synonyms: 4-[Bis(2-chloroethyl)aminophenyl]butyric acid; 4-(p-(N,N-Di-2-chloroethyl)aminophenyl)butyric acid
• Molecular Formula: C₁₄H₁₉Cl₂NO₂
• Molecular Weight: 304.21
• CAS Registry Number: 305-03-3
• EC Number: 206-162-0

Properties

• Melting point: 64 ºC
• Water solubility: <0.01 g/100 mL at 22 ºC

Safety Data

• Hazard Symbols: T
• Risk Codes: R45;R25;R36/37/38
• Safety Description: S53;S26;S45

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	3	H301
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Carcinogenicity	Carc.	1B	H350
Germ cell mutagenicity	Muta.	1B	H340
Reproductive toxicity	Lact.	-	H362
Carcinogenicity	Carc.	1A	H350
Reproductive toxicity	Repr.	1A	H360
Specific target organ toxicity - repeated exposure	STOT RE	2	H373
Skin sensitization	Skin Sens.	1	H317
Reproductive toxicity	Repr.	1B	H360
Specific target organ toxicity - repeated exposure	STOT RE	1	H372
Eye irritation	Eye Irrit.	2A	H319
Germ cell mutagenicity	Muta.	2	H341
Acute toxicity	Acute Tox.	3	H311
Specific target organ toxicity - single exposure	STOT SE	1	H370
Skin sensitization	Skin Sens.	1A	H317

• Transport Information: UN 2811