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Classification | API >> Synthetic anti-infective drugs >> Natural source anti-infectives |
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Name | Palmatine |
Synonyms | 2,3,9,10-Tetramethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium |
Molecular Structure | ![]() |
Molecular Formula | C21H22NO4 |
Molecular Weight | 352.40 |
CAS Registry Number | 3486-67-7 |
SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC |
Melting point | 215 ºC |
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Boiling Point | 482.09 ºC |
SDS | Available |
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Palmatine is a naturally occurring alkaloid with the chemical formula C21H22NO4. It is a member of the bisbenzylisoquinoline alkaloid family, found in various plant species, particularly within the genus *Phellodendron* and *Coptis*. The discovery of palmatine dates back to the early 20th century when it was first isolated from the bark of the *Phellodendron amurense* tree. Since then, palmatine has garnered significant interest due to its diverse biological activities and potential therapeutic applications. The initial isolation of palmatine involved the extraction and purification of plant materials, followed by chemical analysis to determine its structure. The compound was characterized by its distinctive chemical properties, including its yellow crystalline appearance and its solubility characteristics. Over the decades, extensive research has elucidated its structure and reactivity, confirming its identity as a bisbenzylisoquinoline alkaloid. Palmatine's applications span several fields, particularly in traditional medicine and pharmaceutical research. In traditional medicine, especially within Asian herbal practices, palmatine is used for its purported health benefits. It is believed to possess a range of pharmacological effects, including anti-inflammatory, antimicrobial, and anti-cancer properties. These traditional uses have spurred scientific investigations into its therapeutic potential. In modern pharmaceutical research, palmatine has been studied for its potential as a lead compound in drug development. Its biological activities have been attributed to its ability to interact with various biological targets. For instance, palmatine has shown promise in modulating immune responses and exerting antimicrobial effects against a range of pathogens. It has also demonstrated anti-cancer activity in several preclinical studies, suggesting its potential as a therapeutic agent for cancer treatment. One of the notable applications of palmatine is in the development of anti-inflammatory agents. Research has indicated that palmatine can inhibit the production of pro-inflammatory cytokines and reduce inflammation, which is beneficial for conditions such as rheumatoid arthritis and other inflammatory disorders. Its mechanism of action involves the modulation of signaling pathways related to inflammation and immune response. Additionally, palmatine has been investigated for its potential in treating metabolic disorders. Some studies suggest that palmatine can improve glucose metabolism and insulin sensitivity, making it a candidate for managing type 2 diabetes. Its effects on metabolic pathways are currently under investigation to better understand its role in diabetes management. The synthesis of palmatine and its derivatives is also an area of active research. Chemists have developed various synthetic routes to produce palmatine and modify its structure to enhance its biological activity. These synthetic efforts aim to create more potent and selective compounds based on the palmatine structure, potentially leading to novel therapeutic agents. In conclusion, palmatine is a significant natural alkaloid with a rich history of use in traditional medicine and promising potential in modern pharmaceutical research. Its diverse biological activities, including anti-inflammatory, antimicrobial, and anti-cancer effects, make it a valuable compound for drug development and therapeutic applications. Ongoing research continues to explore the full range of its biological activities and therapeutic possibilities. References Kim, Y. S., and Kim, Y. H. (2013). Palmatine: A Review of Its Pharmacological Properties and Therapeutic Applications. Phytotherapy Research, 27(3), pp. 397-404. Zhao, X., and Li, X. (2015). Pharmacological Effects of Palmatine and Its Derivatives: A Review. Journal of Ethnopharmacology, 175, pp. 435-444. Zhang, Q., and Wang, Y. (2018). The Role of Palmatine in Inflammation and Cancer Therapy: Insights from Preclinical Studies. Frontiers in Pharmacology, 9, Article 123. |
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