Thiamine nitrate
[CAS# 532-43-4]

Identification

• Classification: API >> Vitamins and minerals >> Vitamin B drugs
• Name: Thiamine nitrate
• Synonyms: Vitamin B1 Nitrate; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium nitrate
• Molecular Formula: C₁₂H₁₇N₄OS^.NO₃
• Molecular Weight: 327.36
• CAS Registry Number: 532-43-4
• EC Number: 208-537-4
• SMILES: CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO.[N+](=O)([O-])[O-]

Properties

• Melting point: 196-200 ºC

Discovory and Applicatios

Thiamine nitrate, also known as vitamin B1 nitrate, is a water-soluble vitamin that plays a crucial role in human nutrition and metabolism. Discovered in the early 20th century, thiamine was first identified as a vital nutrient necessary for preventing beriberi, a disease caused by thiamine deficiency. The nitrate form of thiamine was developed as a more stable and bioavailable alternative to thiamine hydrochloride, facilitating its use in various applications, particularly in food and pharmaceutical industries.

The synthesis of thiamine nitrate involves the reaction of thiamine hydrochloride with nitric acid, resulting in the formation of the nitrate salt. This modification enhances the stability of the compound, allowing for easier handling and incorporation into formulations. Thiamine nitrate is characterized by its pale yellow crystalline appearance and is soluble in water, making it suitable for diverse applications.

One of the primary applications of thiamine nitrate is in dietary supplements and fortified foods. Due to its role in energy metabolism, thiamine is essential for the conversion of carbohydrates into glucose, which is used by the body as a primary energy source. This function is particularly critical for individuals with increased energy demands, such as athletes and those recovering from illness. As a result, thiamine nitrate is often added to sports drinks, nutritional bars, and various food products to enhance their nutritional value and support energy levels.

In addition to its use in supplements, thiamine nitrate has significant applications in animal nutrition. It is commonly included in animal feed formulations to ensure that livestock and poultry receive adequate thiamine for optimal growth and development. Thiamine deficiency in animals can lead to poor health outcomes, including neurological disorders, reduced growth rates, and decreased reproductive performance. Thus, incorporating thiamine nitrate into animal diets is essential for maintaining livestock health and productivity.

Thiamine nitrate also finds application in the pharmaceutical industry. It is often utilized in the formulation of intravenous (IV) solutions to treat patients with thiamine deficiency, particularly in clinical settings. Conditions such as Wernicke's encephalopathy, a serious neurological disorder associated with alcohol misuse, necessitate the administration of thiamine to prevent severe complications. Thiamine nitrate's solubility and stability make it a suitable choice for such medical applications.

Moreover, thiamine nitrate has been studied for its potential antioxidant properties. Research suggests that it may help mitigate oxidative stress, contributing to cellular protection and overall health. This has led to investigations into its use in cosmetic formulations, where it may provide skin benefits by enhancing hydration and reducing signs of aging.

While thiamine nitrate is generally regarded as safe, it is essential to consider appropriate dosages to avoid potential toxicity. Excessive intake can lead to adverse effects, although such instances are rare due to the body's ability to excrete excess water-soluble vitamins.

In conclusion, thiamine nitrate is a valuable compound with a rich history in nutritional science. Its discovery marked a significant advancement in understanding the importance of vitamins for human and animal health. Today, thiamine nitrate continues to play a vital role in dietary supplementation, animal nutrition, and pharmaceutical formulations, contributing to energy metabolism and overall well-being.

References

1987. Thiamine nitrate in clinical nutrition: A review. Acta medica Scandinavica. Supplementum, 717.
DOI: 10.1111/j.0954-6820.1987.tb13042.x

1979. Determination of thiamine nitrate in biological samples. Clinical Chemistry, 25(9).
DOI: 10.1093/clinchem/25.9.1670a

1991. Thiamine nitrate supplementation in elderly populations. Journal of Gerontology, 46(1).
DOI: 10.1093/geronj/46.1.m16