2-Amino-4,5-dimethylthiazole hydrobromide
[CAS# 7170-76-5]

Identification

• Classification: Flavors and spices >> Synthetic spice >> Lactone and oxygen-containing heterocyclic compound >> Thiazole, thiophene and pyridine
• Name: 2-Amino-4,5-dimethylthiazole hydrobromide
• Synonyms: 4,5-dimethyl-1,3-thiazol-2-amine;hydrobromide
• Molecular Formula: C₅H₈N₂S^.HBr
• Molecular Weight: 209.11
• CAS Registry Number: 7170-76-5
• EC Number: 230-523-1
• SMILES: CC1=C(SC(=N1)N)C.Br

Properties

• Melting point: 287-293 ºC

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P264-P264+P265-P270-P271-P280-P301+P317-P302+P352-P304+P340-P305+P351+P338-P319-P321-P330-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315

Discovory and Applicatios

2-Amino-4,5-dimethylthiazole hydrobromide is an organic compound with the molecular formula C5H9BrN2S. This compound features a thiazole ring, which is a five-membered heterocyclic structure containing both sulfur and nitrogen atoms. The compound is further characterized by amino and methyl groups at the 2, 4, and 5 positions, respectively, with the hydrobromide form enhancing its solubility in water, making it more versatile for various applications in research and industry.

The discovery of 2-Amino-4,5-dimethylthiazole hydrobromide is linked to the broader exploration of thiazole derivatives, which are notable for their chemical reactivity and biological activities. Thiazoles, due to their presence in numerous natural products and their roles in biological systems, have been a focal point in the study of heterocyclic chemistry. The specific properties of 2-Amino-4,5-dimethylthiazole, particularly in its hydrobromide form, have made it an important substance in the synthesis of more complex molecules and in various applications across multiple fields.

One of the primary uses of 2-Amino-4,5-dimethylthiazole hydrobromide is as an intermediate in pharmaceutical synthesis. Its structure is a key building block in the creation of various drugs, particularly those targeting microbial infections, inflammation, and even cancer. The thiazole ring, combined with the amino group, provides a framework that can be further modified to enhance biological activity or improve the pharmacokinetic properties of a drug.

In addition to its pharmaceutical applications, 2-Amino-4,5-dimethylthiazole hydrobromide is also valuable in organic synthesis as a precursor for more complex thiazole derivatives. The reactivity of the amino and methyl groups allows for further chemical transformations, enabling the synthesis of a wide array of compounds. These derivatives can be tailored for specific applications, such as in the development of new materials or in chemical research aimed at discovering novel reactions and products.

The compound is also explored for its potential use in the creation of dyes and pigments. Thiazole rings are known for their ability to interact with light, which can be exploited in the design of compounds with specific optical properties. When combined with other aromatic systems, 2-Amino-4,5-dimethylthiazole hydrobromide can lead to the production of dyes with high color intensity and stability, which are essential qualities in the textile and printing industries.

Furthermore, 2-Amino-4,5-dimethylthiazole hydrobromide has been investigated for applications in agricultural chemistry. Thiazole derivatives have been found to exhibit pesticidal, herbicidal, and fungicidal properties, making them valuable in the development of agrochemicals. The compound's structure can be modified to enhance its efficacy against specific pests or diseases, contributing to more sustainable and effective agricultural practices.

Research into 2-Amino-4,5-dimethylthiazole hydrobromide also includes its potential role in the development of new diagnostic agents. The compound's ability to form stable complexes with metals and other substrates makes it a candidate for use in medical imaging and other diagnostic tools.

In summary, 2-Amino-4,5-dimethylthiazole hydrobromide is a significant compound in both synthetic chemistry and applied sciences. Its discovery and applications have paved the way for advancements in pharmaceuticals, materials science, and agricultural chemistry. The compound's versatility and reactivity, owing to its thiazole ring structure, make it a valuable tool for researchers and industries seeking to develop new products and technologies.