Sodium lauryl polyoxyethylene ether sulfate
[CAS# 9004-82-4]

Identification

• Classification: Surfactant >> Anionic surfactant >> Sulfate type
• Name: Sodium lauryl polyoxyethylene ether sulfate
• Synonyms: Poly(oxy-1,2-ethanediyl)-alpha-sulfo-omega-(dodecyloxy)-sodium salt; AES
• CAS Registry Number: 9004-82-4
• EC Number: 688-491-3
• SMILES: CCCCCCCCCCCCOCCOS(=O)(=O)[O-].[Na+]

Safety Data

• Hazard Symbols: GHS05;GHS07 Danger
• Hazard Statements: H302-H315-H318-H319
• Precautionary Statements: P264-P264+P265-P270-P280-P301+P317-P302+P352-P305+P351+P338-P305+P354+P338-P317-P321-P330-P332+P317-P337+P317-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319

Discovory and Applicatios

Sodium lauryl polyoxyethylene ether sulfate (SLES) is an anionic surfactant widely used in detergents and personal care products. It is a member of the alkyl ether sulfate family, where a lauryl (dodecyl) alkyl chain is linked through a polyoxyethylene (ethylene oxide) chain to a sulfate group. The development of SLES traces back to the mid-20th century, following the broader commercialization of ethoxylated surfactants, which improved the mildness and performance of earlier alkyl sulfates like sodium lauryl sulfate (SLS).

SLES is synthesized by first ethoxylating lauryl alcohol with a controlled average number of ethylene oxide units, typically between 1 and 3 moles of ethylene oxide per mole of lauryl alcohol, to form lauryl polyoxyethylene ethers. This is followed by sulfation using chlorosulfonic acid or sulfur trioxide to convert the terminal hydroxyl group into a sulfate ester. The resulting crude product is neutralized with sodium hydroxide to yield sodium lauryl polyoxyethylene ether sulfate. The degree of ethoxylation affects the surfactant’s hydrophilic-lipophilic balance (HLB), foam stability, detergency, and mildness. Typical commercial products contain about 70% active surfactant in aqueous solution.

SLES is valued for its strong foaming ability, excellent detergency, and relatively low skin irritation compared to non-ethoxylated alkyl sulfates. It is extensively used in shampoos, body washes, facial cleansers, household cleaning agents, and liquid soaps. Its ethoxylated structure confers improved compatibility with other surfactants and formulation ingredients, enhancing stability and product aesthetics. Moreover, SLES retains good biodegradability and low aquatic toxicity when appropriately formulated, making it suitable for widespread consumer use.

The mildness of SLES relative to sodium lauryl sulfate has been confirmed in numerous dermatological studies. While sodium lauryl sulfate is recognized for its irritant potential, especially at higher concentrations, SLES shows reduced irritation due to the ethoxylation step, which increases water solubility and reduces the critical micelle concentration. Nonetheless, product formulations carefully balance SLES concentration to maximize cleansing efficacy without compromising skin barrier integrity. SLES is often combined synergistically with amphoteric surfactants such as cocamidopropyl betaine to further enhance mildness and foaming characteristics.

Environmental and toxicological profiles of SLES have been extensively reviewed. It is readily biodegradable under aerobic conditions and does not tend to bioaccumulate. Aquatic toxicity studies indicate low to moderate toxicity toward freshwater organisms, but risk is mitigated by dilution and wastewater treatment. Human safety data confirm that SLES does not exhibit genotoxicity or carcinogenicity. However, occupational exposure to high concentrations, especially in industrial cleaning settings, may cause skin and eye irritation; thus, appropriate handling measures are recommended.

Recent research continues to optimize SLES synthesis for better control of ethoxylation degree and sulfation efficiency, aiming to improve product consistency and reduce impurities such as 1,4-dioxane, a potential contaminant formed during ethoxylation. Innovations in greener sulfation methods and enzymatic ethoxylation are under investigation to enhance sustainability. Moreover, SLES derivatives with tailored ethylene oxide chain lengths are designed to meet specific formulation needs, balancing foam, mildness, and detergency.

In summary, sodium lauryl polyoxyethylene ether sulfate is a cornerstone surfactant in personal care and household cleaning products, combining strong cleansing and foaming with improved mildness over traditional alkyl sulfates. Developed through ethoxylation and sulfation of lauryl alcohol, it offers formulation flexibility and environmental compatibility. Continued advances in synthesis and formulation maintain its relevance in consumer and industrial applications worldwide.

References

Aoudia M, Al‑Haddabi B, Al‑Harthi Z, Al‑Rubkhi A (2010) Sodium lauryl ether sulfate micellization and water solubility enhancement toward naphthalene and pyrene: effect of the degree of ethoxylation. Journal of Surfactants and Detergents 13(1):103–111 DOI: 10.1007/s11743-009-1131-9

Hendrikse RL, Zumpano R, Esposito R et al. (2022) Structure and dynamics of sodium lauryl ether sulfate micelles: effect of ethoxylation polydispersity. The Journal of Physical Chemistry B 126(28):5534–5543 DOI: 10.1021/acs.jpcb.2c04329

Robinson VC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Marks JG Jr et al. (2010) Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols. International Journal of Toxicology 29(4):151S–161S DOI: 10.1177/1091581810373151