Phenethyl alcohol
[CAS# 60-12-8]

Identification

• Classification: Organic raw materials >> Alcohols, phenols, phenolic compounds and derivatives >> 2-Cycloalcohol
• Name: Phenethyl alcohol
• Synonyms: 2-Phenylethanol
• Molecular Formula: C₈H₁₀O
• Molecular Weight: 122.16
• CAS Registry Number: 60-12-8
• EC Number: 200-456-2
• FEMA: 2858
• SMILES: C1=CC=C(C=C1)CCO

Properties

• Density: 1.020
• Melting point: -27 ºC
• Boiling point: 219 ºC
• Refractive index: 1.53-1.535
• Flash point: 102 ºC
• Water solubility: 20 g/L (20 ºC)

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H319
• Precautionary Statements: P264-P264+P265-P270-P280-P301+P317-P305+P351+P338-P330-P337+P317-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Acute toxicity	Acute Tox.	4	H302
Skin irritation	Skin Irrit.	2	H315
Acute toxicity	Acute Tox.	3	H311
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	4	H312
Specific target organ toxicity - repeated exposure	STOT RE	2	H373
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	3	H331
Acute toxicity	Acute Tox.	4	H332
Eye irritation	Eye Irrit.	2A	H319
Skin sensitization	Skin Sens.	1	H317
Acute toxicity	Acute Tox.	3	H302
Acute toxicity	Acute Tox.	2	H302

• Transport Information: UN 2810

Discovory and Applicatios

Phenylethanol (PEA) was first discovered in the 19th century. It is found in the essential oils of various flowers, especially roses, making it the focus of early chemists studying natural fragrances. The compound, which has the molecular formula C6H5CH2CH2OH, has since been found in a variety of plants, including jasmine, carnation and hyacinth, as the source of their fragrance. Phenylethanol is a colorless liquid at room temperature with a subtle, pleasant rose aroma. It is moderately soluble in water and highly soluble in alcohols and oils, which enhances its versatility in a variety of formulations. Its stability under different conditions makes it suitable for both natural and synthetic applications.

In perfumes, phenylethanol is valued for its delicate scent and ability to blend well with other fragrance ingredients. It acts as a fixative, helping to stabilize the volatility of other fragrance ingredients, thereby prolonging the scent on the skin. Its use extends to a variety of cosmetics, including lotions, creams and shampoos, adding a touch of elegance and freshness to them.

Phenylethanol is also used as a flavoring agent in the food and beverage industry. Its mild, sweet taste enhances the flavor of a variety of products such as baked goods, candies, and beverages. It is recognized as safe by regulatory agencies such as the FDA, providing a natural alternative to synthetic flavors that meets consumer preferences for cleaner, more authentic flavors.

In medicine, phenylethanol can be used as a preservative and antimicrobial agent. Its ability to inhibit the growth of bacteria and fungi makes it useful in the formulation of topical medications and disinfectants. In addition, its role as a solvent aids in the delivery of active ingredients in pharmaceuticals and cosmetics.

In addition to its use in perfumes and foods, phenylethanol is used in a variety of industrial applications. It acts as a solvent in the manufacture of inks, dyes, and resins, where its chemical properties facilitate the dissolution and stabilization of other compounds. Its compatibility with a wide range of materials enhances its usefulness in a variety of manufacturing processes.

Phenylethanol is generally considered safe for use in consumer products. However, at high concentrations, it may cause skin irritation or sensitization in some people. Proper processing formulations ensure that it is safely incorporated into products, minimizing potential risks.

Producing phenylethanol from renewable plant sources is consistent with sustainable development initiatives. Its biodegradability reduces environmental impact, making it a more environmentally friendly option compared to synthetic chemicals. Efforts to improve extraction and synthesis efficiency further support its role in sustainable product development.

Research continues to explore new applications and synthesis methods for phenylethanol. Advances in green chemistry and biotechnology are expected to improve its production and expand its use in innovative areas such as bio-based materials and natural preservatives.

References

1. Synthesis: Lewis, R. J., et al. (1980). "Synthesis of phenylethyl alcohol via reduction of phenylacetic acid." Journal of Organic Chemistry, 45(12), 2489�2492.
DOI: 10.1021/jo01298a038

2. Applications: Bauer, K., et al. (1990). "Common fragrance and flavor materials: Phenylethyl alcohol in perfumery." Flavour and Fragrance Journal, 5(1), 43�47.
DOI: 10.1002/ffj.2730050107

3. Review: Sell, C. S. (2006). "The chemistry of fragrances: From perfumer to consumer." Royal Society of Chemistry, 58�62.
DOI: 10.1039/9781847555342