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N2-(4-fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine
[CAS# 792184-90-8]

Identification
Classification Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Amine
Name N2-(4-fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine
Synonyms ASP-2905; 2-N-(4-fluorophenyl)-4-N-phenyl-6-N-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine
Molecular Formula C20H17FN8
Molecular Weight 388.40
CAS Registry Number 792184-90-8
SMILES C1=CC=C(C=C1)NC2=NC(=NC(=N2)NCC3=NC=CC=N3)NC4=CC=C(C=C4)F
up Discovory and Applicatios
N2-(4-Fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine is a complex organic molecule that belongs to the class of triazine-based compounds, which are known for their diverse applications in chemical and pharmaceutical industries. This compound features a 1,3,5-triazine core, a structure commonly utilized in medicinal chemistry due to its biological activity and versatility in molecular modifications. The presence of a fluorophenyl group, a phenyl group, and a pyrimidin-2-ylmethyl group linked to the triazine core adds specific chemical functionalities that allow this compound to interact with various biological targets, making it a candidate for therapeutic applications.

The discovery of triazine-based compounds, including N2-(4-fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine, can be traced back to the early 20th century when chemists first explored the triazine ring for its stability and ability to undergo diverse chemical reactions. Over time, triazine derivatives gained prominence due to their applications in agriculture, such as herbicides (e.g., atrazine), and their potential in pharmaceuticals for treating diseases like cancer and inflammation. The incorporation of fluorine atoms, as seen in this compound, is a strategic modification often used in drug design to enhance the bioavailability and metabolic stability of molecules.

One of the key applications of N2-(4-fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine is its potential use as an inhibitor of protein kinases. Protein kinases are enzymes that play critical roles in cellular signaling pathways, and their dysregulation is associated with several diseases, including cancer. The triazine core, combined with the fluorophenyl and pyrimidinyl groups, enables this compound to bind selectively to the active site of kinases, blocking their activity and thereby preventing abnormal cell growth. This makes the compound a valuable lead structure in the development of targeted cancer therapies.

In addition to its potential in oncology, this compound has applications in the field of anti-inflammatory drug development. Triazine-based structures are known to inhibit enzymes involved in the inflammatory response, such as cyclooxygenase (COX) enzymes. The phenyl and fluorophenyl groups attached to the triazine core can modulate the binding affinity of the compound to these enzymes, leading to anti-inflammatory effects. Such compounds are of interest for treating chronic inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.

Another important application of N2-(4-fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine is in the area of antimicrobial research. The triazine ring and its derivatives have been investigated for their ability to disrupt bacterial and fungal cell processes. This compound’s structure can be modified to enhance its antimicrobial activity, offering a promising approach in the fight against antibiotic-resistant pathogens.

In summary, N2-(4-fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine represents an important compound with broad potential in the development of cancer therapeutics, anti-inflammatory agents, and antimicrobial drugs. The unique combination of a triazine core with fluorophenyl, phenyl, and pyrimidinyl groups makes it a versatile lead structure for future pharmaceutical innovations.
Market Analysis Reports
List of Reports Available for N2-(4-fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine
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