Zinc citrate
[CAS# 546-46-3]

Identification

• Classification: Organic raw materials >> Organometallic compound >> Organic zinc
• Name: Zinc citrate
• Synonyms: Trizinc 2-hydroxypropane-1,2,3-tricarboxylate
• Molecular Formula: Zn3(C₆H₅O₇)₂
• Molecular Weight: 574.37
• CAS Registry Number: 546-46-3
• EC Number: 208-901-2
• SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Zn+2].[Zn+2].[Zn+2]

Properties

• Melting point: 334 ºC (Decomposes) (Expl.)
• Solubility: soluble (dilute mineral acids, alkali hydroxides), slightly soluble (water) (Expl.)

Safety Data

• Hazard Symbols: GHS07;GHS09 Warning
• Hazard Statements: H319-H400-H410-H411
• Precautionary Statements: P264+P265-P273-P280-P305+P351+P338-P337+P317-P391-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400
Eye irritation	Eye Irrit.	2	H319
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410

• Transport Information: UN 3077

Discovory and Applicatios

Zinc citrate is an inorganic coordination compound in which zinc ions are complexed with citrate anions, typically in the form Zn₃(C₆H₅O₇)₂. It occurs as a white to slightly off-white powder and is only sparingly soluble in water. Zinc citrate is notable for its combination of zinc’s physiological and antimicrobial properties with citrate’s chelating and buffering characteristics, making it useful in both nutritional and hygienic applications.

The development of zinc citrate as a functional ingredient dates back to research into zinc-containing compounds for dental health in the late 20th century. It was introduced primarily as an alternative to zinc chloride or zinc sulfate in oral care products, offering similar antibacterial activity with reduced astringency and lower irritation potential. Its low solubility in water allows for gradual release of zinc ions, providing a sustained antimicrobial effect in the oral cavity.

One of the most prominent applications of zinc citrate is in toothpaste and mouthwash formulations, where it helps inhibit the growth of oral bacteria responsible for plaque formation, halitosis, and gingivitis. It acts by interfering with bacterial glycolysis, destabilizing cell membranes, and inhibiting the formation of volatile sulfur compounds that contribute to bad breath. Its plaque-control efficacy has led to its inclusion in a range of commercial dentifrices, often in combination with fluoride to provide both antimicrobial and enamel-protective benefits.

Zinc citrate is also used as a dietary zinc supplement to help prevent or correct zinc deficiency. As an essential trace element, zinc is involved in numerous enzymatic processes, immune system function, and wound healing. The citrate form offers relatively good bioavailability compared to some other insoluble zinc salts, while being well tolerated in terms of gastrointestinal side effects. Supplement formulations may include zinc citrate either alone or blended with other mineral salts and vitamins.

Beyond nutritional and oral health uses, zinc citrate has applications in functional food fortification, personal care products, and as a mild antimicrobial agent in certain topical formulations. In cosmetic products, it can be found in deodorants and skin-care items, where zinc ions help suppress odor-causing bacteria. Its role as a buffering agent and metal ion source also makes it relevant in some pharmaceutical preparations.

In industrial and technical contexts, zinc citrate has been investigated as a biodegradable chelating agent in cleaning and metal treatment formulations, where the citrate ligand can complex metal ions while the zinc component contributes antimicrobial properties. Although less common than other zinc salts in agriculture, it has potential as a micronutrient source for zinc-deficient soils due to its relatively low environmental persistence and gradual zinc release.

From a safety standpoint, zinc citrate is generally recognized as safe (GRAS) for use in foods and oral care products when used within established concentration limits. Excessive intake, however, can lead to zinc toxicity, characterized by gastrointestinal disturbances and interference with copper metabolism. Its environmental profile is considered favorable when used in regulated applications, as citrate is biodegradable and zinc is an essential element, though accumulation in aquatic environments should be avoided.

References

2014. Zinc Absorption by Young Adults from Supplemental Zinc Citrate Is Comparable with That from Zinc Gluconate and Higher than from Zinc Oxide. The Journal of Nutrition, 144(2).
DOI: 10.3945/jn.113.181487
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901420